5-Amino-1MQ

A new approach to metabolic research
5-Amino-1MQ (CAS 42404-74-4) is a potent, cell-permeable small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT) a metabolic enzyme increasingly recognized for its role in obesity, insulin resistance, and energy homeostasis.

By blocking NNMT, the compound conserves NAD⁺ and S-adenosylmethionine (SAM), two critical cofactors that drive mitochondrial activity and epigenetic regulation. This mechanism makes it a uniquely valuable tool for researchers studying metabolic syndrome, adipocyte biology, and NAD⁺ salvage pathways.

NNMT inhibition, NAD⁺ amplification
NNMT catalyses the methylation of nicotinamide using SAM as a methyl donor, consuming both molecules and limiting NAD⁺ availability. 5-Amino-1MQ competitively blocks this reaction, preserving the methionine cycle and restoring cellular energy cofactors.

The downstream result is a shift toward increased fat oxidation, white-to-beige adipocyte conversion, and enhanced mitochondrial thermogenesis effects well-documented in murine obesity models.